Gut hormones in adaptation.

Regulation of gene expression in pancreatic adaptation to nutritional substrates or hormones.

Osmoregulatory Parameters of Asian sea bass (Lates calcarifer) during adaptation in Freshwater

In the present study, the adaptation of Asian sea bass (lates calcarifer) was investigated in fresh water using physiological parameters of osmoregulation including: the plasma levels of thyroid hormones and cortisol, gill Na+/ K+-ATPase activity and plasma concentrations of sodium and chloride. For this purpose, 60 fish were distributed in three 300 L tanks with a density of 20 fish per tank. ...

Attenuation by l-thyroxine of oxidant-induced gut epithelial damage

Objective(s): Severe injuries are often associated with tissue hypothyroidism, elevated damaging mediators in circulation, and broken gut epithelial barrier.  However, the relationships between the hypothyroid state and gut epithelial damage are largely unknown.  Therefore, in this study, we investigated the effects of L-thyroxine (T4) on in vitro models of intact and ...

Gut hormones in gastrointestinal disease.

Considerable advances have been made in the understanding of the physiology of gut hormones. Thus, knowledge of the mechanisms of release and of the actions of many of the hormones is rapidly expanding. The known clinical importance of gut hormones is at present confined only to the excess production of gastrin, VIP, and pancreatic glucagon by endocrine tumours. The role of these three and the ...

Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats

OBJECTIVE To determine the effects of exogenous glucagon-like peptide-2 (GLP-2), with or without massive distal bowel resection, on adaptation of jejunal mucosa, enteric neurons, gut hormones and tissue reserves in rats. BACKGROUND GLP-2 is a gut hormone known to be trophic for small bowel mucosa, and to mimic intestinal adaptation in short bowel syndrome (SBS). However, the effects of exogen...